12. Nutrigenomic Perspectives on Cancer Chemoprevention with Anti-Inflammatory and Antioxidant Phytochemicals: NF-κB and Nrf2 Signaling Pathways as Potential Targets

  1. Debasis Bagchi Ph.D.3,
  2. Francis C. Lau Ph.D.4 and
  3. Manashi Bagchi Ph.D.4
  1. Hye-Kyung Na1 and
  2. Young-Joon Surh2

Published Online: 25 MAR 2010

DOI: 10.1002/9780813821474.ch12

Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods

Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods

How to Cite

Na, H.-K. and Surh, Y.-J. (2010) Nutrigenomic Perspectives on Cancer Chemoprevention with Anti-Inflammatory and Antioxidant Phytochemicals: NF-κB and Nrf2 Signaling Pathways as Potential Targets, in Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods (eds D. Bagchi, F. C. Lau and M. Bagchi), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813821474.ch12

Editor Information

  1. 3

    Department of Pharmacology and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA

  2. 4

    Dept. of Research and Development, InterHealth Research Center, 5451 Industrial Way, Benicia, CA, USA

Author Information

  1. 1

    Dept. of Food and Nutrition, College of Human Ecology, Sungshin Women's University, Seoul, 136-742, South Korea

  2. 2

    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea

Publication History

  1. Published Online: 25 MAR 2010
  2. Published Print: 9 APR 2010

ISBN Information

Print ISBN: 9780813814025

Online ISBN: 9780813821474

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Keywords:

  • Molecular-Based Cancer Chemoprevention;
  • Nuclear Factor-Kappa B (NF-κB);
  • antioxidant enzymes via interaction with a cis-acting DNA;
  • Nuclear Factor Erythroid 2 (NF-E2)-Related Factor (NRF2);
  • crosstalk Between NRF2 and NF-κB Signaling Pathways;
  • DNA damage via upregulation of NQO1

Summary

This chapter contains sections titled:

  • Introduction

  • Molecular-Based Cancer Chemoprevention

  • Nuclear Factor-Kappa B (NF-κB)

  • Nuclear Factor Erythroid 2 (NF-E2)-Related Factor (NRF2)

  • Crosstalk between NRF2 and NF-κB Signaling Pathways

  • Conclusion

  • Acknowledgments

  • References