4. Approaches and Practical Considerations for the Analysis of Toxicogenomics Data
- Darrell R. Boverhof,
- B. Bhaskar Gollapudi
Published Online: 18 JUL 2011
DOI: 10.1002/9781118001042.ch4
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
Additional Information
How to Cite
Su, Z., Fang, H., Tong, W., Hong, H., Perkins, R., Guo, L. and Shi, L. (2011) Approaches and Practical Considerations for the Analysis of Toxicogenomics Data, in Applications of Toxicogenomics in Safety Evaluation and Risk Assessment (eds D. R. Boverhof and B. B. Gollapudi), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118001042.ch4
Editor Information
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, USA
Publication History
- Published Online: 18 JUL 2011
- Published Print: 18 JUL 2011
ISBN Information
Print ISBN: 9780470449820
Online ISBN: 9781118001042
- Summary
- Chapter
- References
Keywords:
- toxicogenomics data analysis - critical step in microarray gene study, identifying differentially expressed genes (DEGs);
- gene identification methods, and performance assessment - of DEG identification approaches;
- FC ranking and p-value cutoff, identifying DEGs - nature of data and microarray application, trade-off between sensitivity and specificity
Summary
This chapter contains sections titled:
Introduction
Concerns on the Reproducibility of Microarray Data
Many Different Ways for Identifying Differentially Expressed Genes (DEGs)
Assessing the Performance of Gene Identification Methods
A Toxicogenomics Case Study
Drawback of p-Value Ranking in Analyzing Microarray Data
Toward Consensus: Fold-Change Ranking with a Nonstringent p-Value Cutoff
Conclusions
References