1. Epigenetic Modulation of Cell Cycle: An Overview

  1. Antonio Giordano1,2,3 and
  2. Marcella Macaluso1
  1. Micaela Montanari1,
  2. Antonio Giordano1,2,3,
  3. Marcella Cintorino2 and
  4. Marcella Macaluso1

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch1

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Montanari, M., Giordano, A., Cintorino, M. and Macaluso, M. (2011) Epigenetic Modulation of Cell Cycle: An Overview, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch1

Editor Information

  1. 1

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 2

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 3

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. 1

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 2

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 3

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • epigenetics and cell cycle - epigenetic modulation of cell cycle;
  • epigenetic and genetic alterations of pRb and p53 pathways - cell cycle progression, surveillance mechanisms, and cell cycle checkpoint;
  • intricate crosstalk of signals connecting pRb (pRb/p16INK4/cyclin D1) and p53 pathways - regulating cell cycle progression and viability

Summary

This chapter contains sections titled:

  • Introduction

  • Epigenetic and Genetic Alterations of pRb and p53 Pathways

  • Conclusion

  • References