12. Potential of Heat Shock Protein Targeting for Human Therapy

  1. Antonio Giordano2,3,4 and
  2. Marcella Macaluso2
  1. Laszlo Otvos Jr.

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch12

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Otvos, L. (2011) Potential of Heat Shock Protein Targeting for Human Therapy, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch12

Editor Information

  1. 2

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 3

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 4

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. PeptheRx, Inc., Audubon, Pennsylvania, USA

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • potential of heat shock protein targeting - for human therapy;
  • protein misfolding diseases - proteins, permanently or transiently correct folded state;
  • Hsp90, as a novel oncology target - Hsp90 inhibition, avenues in combating cancer forms

Summary

This chapter contains sections titled:

  • Folding of Nascent Proteins In Vitro and In Vivo

  • More Hsp90

  • Protein Misfolding Diseases

  • Hsp60 and Hsp70 Inhibitors

  • Positive Therapeutic Effects of Hsp70 Upregulation

  • Hsp90 as a Novel Oncology Target

  • Hsp90 Inhibitors in Preclinical and Clinical Trials

  • Alternative Hsp90 Targeting Strategies

  • Potential Problems in Hsp90 Inhibition

  • Vaccine Candidates Based on Heat Shock Protein-Substrate Complexes

  • References