12. Potential of Heat Shock Protein Targeting for Human Therapy
- Antonio Giordano2,3,4,
- Marcella Macaluso2
Published Online: 3 JUN 2011
DOI: 10.1002/9781118005743.ch12
Copyright © 2011 Wiley-Blackwell.
Book Title
Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer
Additional Information
How to Cite
Otvos, L. (2011) Potential of Heat Shock Protein Targeting for Human Therapy, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch12
Editor Information
- 2
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
- 3
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
- 4
Oncology Research Centre of Mercogliano (CROM), Avellino, Italy
Publication History
- Published Online: 3 JUN 2011
- Published Print: 27 JUN 2011
ISBN Information
Print ISBN: 9780471710967
Online ISBN: 9781118005743
- Summary
- Chapter
- References
Keywords:
- potential of heat shock protein targeting - for human therapy;
- protein misfolding diseases - proteins, permanently or transiently correct folded state;
- Hsp90, as a novel oncology target - Hsp90 inhibition, avenues in combating cancer forms
Summary
This chapter contains sections titled:
Folding of Nascent Proteins In Vitro and In Vivo
More Hsp90
Protein Misfolding Diseases
Hsp60 and Hsp70 Inhibitors
Positive Therapeutic Effects of Hsp70 Upregulation
Hsp90 as a Novel Oncology Target
Hsp90 Inhibitors in Preclinical and Clinical Trials
Alternative Hsp90 Targeting Strategies
Potential Problems in Hsp90 Inhibition
Vaccine Candidates Based on Heat Shock Protein-Substrate Complexes
References