14. Epigenetic Targets and Drug Development

  1. Antonio Giordano4,5,6 and
  2. Marcella Macaluso4
  1. Paraskevi Vogiatzi1,2,
  2. Maria Irene Scarano1 and
  3. Pier Paolo Claudio3,4

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch14

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Vogiatzi, P., Scarano, M. I. and Claudio, P. P. (2011) Epigenetic Targets and Drug Development, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch14

Editor Information

  1. 4

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 5

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 6

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. 1

    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, USA

  2. 2

    Department of Molecular Biology, University of Siena, Siena, Italy

  3. 3

    Marshall University, Department of Biochemistry and Microbiology, Huntington, West Virginia, USA

  4. 4

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • epigenetic targets and drug development - epigenetic events, gene function, selectively activated or inactivated;
  • RNA interference, evolutionarily conserved mechanism - of posttranscriptional gene silencing;
  • epigenetic drugs, and potential pitfalls - nucleoside analog inhibitors, reactivating silenced genes inhibiting DNA methylation toxicity

Summary

This chapter contains sections titled:

  • Epigenetics: Basic Mechanisms of the Changing Image of the Gene

  • Current Epigenetic Interventions in Therapy

  • DNA Methylation Inhibitors

  • RNA Interference

  • Histone Deacetylase Inhibitors

  • The Potential Pitfalls of Epigenetic Drugs

  • References