3. Epigenetic Control in Cellular Senescence

  1. Antonio Giordano2,3,4 and
  2. Marcella Macaluso2
  1. Heike Helmbold,
  2. Wolfgang Deppert and
  3. Wolfgang Bohn

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch3

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Helmbold, H., Deppert, W. and Bohn, W. (2011) Epigenetic Control in Cellular Senescence, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch3

Editor Information

  1. 2

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 3

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 4

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, University of Hamburg, Hamburg, Germany

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743



  • cellular senescence and epigenetic control - entry of cells, into irreversible G1/S growth arrest;
  • cellular senescence, natural barrier to oncogenic transformation - benign, or premalignant lesions;
  • senescence arrest, and chromatin organizational changes - features of repressed chromatin


This chapter contains sections titled:

  • From Replicative Senescence to DNA Damage Response

  • Cellular Senescence, a Natural Barrier to Oncogenic Transformation

  • Regulation of Senescence Pathways

  • From Growth Arrest to Gene Silencing in Cellular Senescence

  • References