4. Epigenetic Modulation in Cell Development and Differentiation

  1. Antonio Giordano2,3,4 and
  2. Marcella Macaluso2
  1. Mario Mancino,
  2. Claudia Esposito,
  3. Raffaella Pasquale,
  4. Immacolata Vocca and
  5. Francesca Pentimalli

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch4

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Mancino, M., Esposito, C., Pasquale, R., Vocca, I. and Pentimalli, F. (2011) Epigenetic Modulation in Cell Development and Differentiation, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch4

Editor Information

  1. 2

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 3

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 4

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. INT–CROM, Pascale Foundation National Cancer Institute–Cancer Research Center, Mercogliano, Avellino, Italy

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • epigenetic modulation in cell development and differentiation - epigenetic alterations to chromatin, in development;
  • epigenetic regulation of transposable elements - transposons, silenced completely and stably, preventing mutations;
  • vertebrates, pluripotency regulation - genes and pluripotency, silenced by histone modification and/or DNA methylation

Summary

This chapter contains sections titled:

  • Epigenetics: An Overview

  • Chromatin Structure and Epigenetics

  • Analysis of Epigenetic Alterations to Chromatin during Development

  • Epigenetic Regulation of Transposable Elements

  • Conclusion

  • References