5. Epigenetic Control of Gene Transcription

  1. Antonio Giordano3,4,5 and
  2. Marcella Macaluso3
  1. Christian Bronner1,
  2. Mayada Achour1,
  3. Thierry Chataigneau2 and
  4. Valérie B. Schini-Kerth1

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch5

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Bronner, C., Achour, M., Chataigneau, T. and Schini-Kerth, V. B. (2011) Epigenetic Control of Gene Transcription, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch5

Editor Information

  1. 3

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 4

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 5

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. 1

    Laboratoire de Biophotonique et de Pharmacologie, UMR 7213 CNRS, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France

  2. 2

    Laboratoire de Biophotonique et de Pharmacologie, UMR 7213 CNRS, Université de Strasbourg, Illkirch, France

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • epigenetics and gene transcription - enzymatic machinery, DNA genetic code into RNA code (transcription);
  • cross-talk between DNA methylation and histone modifications - linked, changes in DNA methylation influencing histone code;
  • molecular basis for epigenetic information in histone tails, and memorization - unknown till now, helping in understanding epigenetic code transmission

Summary

This chapter contains sections titled:

  • Introduction

  • Chromatin Structure and Basal Transcription Machinery

  • DNA Methylation

  • Histone Modifications

  • Cross-Talk Between DNA Methylation and Histone Modifications

  • Replication, Repair, and Transmission of the Epigenetic Code: The Cellular Memory

  • References