7. The Role of Epigenetic Modifications in Cancer

  1. Antonio Giordano2,3,4 and
  2. Marcella Macaluso2
  1. Michael J. Powell,
  2. Vladimir M. Popov,
  3. Xiang Wang,
  4. Steven B. McMahon,
  5. Alexander Mazo and
  6. Richard G. Pestell

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch7

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Powell, M. J., Popov, V. M., Wang, X., McMahon, S. B., Mazo, A. and Pestell, R. G. (2011) The Role of Epigenetic Modifications in Cancer, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch7

Editor Information

  1. 2

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 3

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 4

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. Kimmel Cancer Center, Departments of Cancer Biology, Medical Oncology, Microbiology and Immunology, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • epigenetics and cancer, and epigenetic modifications - regulator protein role in epigenetic modifications;
  • nonhistone protein posttranslational modification, and cancer - NRs, transcriptional regulators and homeostasis control;
  • histone deacetylase inhibitors and cancer - globular histone octomers, eukaryotic chromatin, H2A, H2B, H3 and H4 histone proteins

Summary

This chapter contains sections titled:

  • Introduction to Epigenetics

  • Polycomb and Trithorax Gene Families Contain Epigenetic Modifiers Commonly Altered in Human Cancers

  • Posttranslational Modification of Nonhistone Proteins Involved in Cancer

  • Methylation Status in Cancer

  • Histone Deacetylase Inhibitors and Cancer

  • Concluding Remarks and Perspective

  • References