8. MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases

  1. Antonio Giordano4,5,6 and
  2. Marcella Macaluso4
  1. Serena Buontempo1,
  2. Mara Sannai2 and
  3. Alfonso Bellacosa3

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch8

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Buontempo, S., Sannai, M. and Bellacosa, A. (2011) MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch8

Editor Information

  1. 4

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 5

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 6

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. 1

    Laboratory of Stem Cells Epigenetics, European Institute of Oncology, Milan, Italy

  2. 2

    Laboratory of Genomic Stability, Leibniz Institute for Age Research, Jena, Germany

  3. 3

    Cancer Biology Program, Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743

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Keywords:

  • MBD4/MED1 protein in DNA repair - and demethylation, cancer and other diseases;
  • MBD4/MED1 identification, and domain structure - biochemical activity, MBD4 functions underscored by history of its identification;
  • MBD4/MED1 alterations in disease and cancer - MBD4, inactivated in cancer, and in SLE, an increased expression of MBD4

Summary

This chapter contains sections titled:

  • Introduction

  • Identification of MBD4/MED1: Domain Structure and Biochemical Activity

  • MBD4/MED1 in the DNA Damage Response and Induction of Apoptosis

  • Role in Epigenetic Regulation and DNA Demethylation

  • MBD4/MED1 Alterations in Disease and Cancer

  • Conclusion and Future Perspectives

  • References