9. Epigenetics in Pediatric Cancers

  1. Antonio Giordano2,3,4 and
  2. Marcella Macaluso2
  1. Roberta Ciarapica,
  2. Lavinia Raimondi,
  3. Federica Verginelli and
  4. Rossella Rota

Published Online: 3 JUN 2011

DOI: 10.1002/9781118005743.ch9

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer

How to Cite

Ciarapica, R., Raimondi, L., Verginelli, F. and Rota, R. (2011) Epigenetics in Pediatric Cancers, in Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer (eds A. Giordano and M. Macaluso), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118005743.ch9

Editor Information

  1. 2

    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA

  2. 3

    Department of Human Pathology and Oncology, University of Siena, Siena, Italy

  3. 4

    Oncology Research Centre of Mercogliano (CROM), Avellino, Italy

Author Information

  1. Laboratory of Endothelial Cells and Angiogenesis, Ospedale Pediatrico Bambino Gesù, Rome, Italy

Publication History

  1. Published Online: 3 JUN 2011
  2. Published Print: 27 JUN 2011

ISBN Information

Print ISBN: 9780471710967

Online ISBN: 9781118005743



  • epigenetics in pediatric cancers - epigenetics, newest research front, unraveling nuanced world of gene expression;
  • neuroblastoma (NB), a PNT (peripheral neuroblastic tumor) - one of the most common solid cancers in children, below age five;
  • pediatric neuroectodermal-derived tumors - medulloblastoma (MB), prevalent brain tumor in children, the WHO grade IV malignant brain tumor in childhood


This chapter contains sections titled:

  • Introduction

  • Leukemia in Childhood

  • Neuroblastoma

  • Rhabdomyosarcoma (RMS)

  • Wilms Tumor

  • Retinoblastoma

  • Primary Central Nervous System Malignancies in Childhood

  • Pediatric Glial-Cell-Derived Tumors

  • Pediatric Neuroectodermal-Derived Tumors

  • References