4. Nonrandom Chromosome Abnormalities in Cancer—An Overview

  1. Sverre Heim1 and
  2. Felix Mitelman2
  1. Sverre Helm and
  2. Felix Mitelman

Published Online: 4 OCT 2010

DOI: 10.1002/9781118010136.ch4

Cancer Cytogenetics, THIRD EDITION

Cancer Cytogenetics, THIRD EDITION

How to Cite

Helm, S. and Mitelman, F. (2010) Nonrandom Chromosome Abnormalities in Cancer—An Overview, in Cancer Cytogenetics, THIRD EDITION (eds S. Heim and F. Mitelman), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118010136.ch4

Editor Information

  1. 1

    Department of Medical Genetics Oslo University Hospital, Norway

  2. 2

    Department of Clinical Genetics Lund University Hospital, Sweden

Publication History

  1. Published Online: 4 OCT 2010
  2. Published Print: 15 MAR 2010

ISBN Information

Print ISBN: 9780470181799

Online ISBN: 9781118010136



  • nonrandom chromosome abnormalities;
  • comparative genomic hybridization;
  • karyotypic abnormalities;
  • philadelphia chromosome;
  • cytogenetic techniques


This chapter contains sections titled:

  • Primary and Secondary Neoplasia-Associated Chromosome Abnormalities

  • Why and How do Chromosome Aberrations Arise?

  • When do Chromosome Aberrations Arise?

  • In Which Cells do Chromosome Aberrations Arise?

  • Are Acquired Chromosome Aberrations Sufficient for Neoplastic Proliferation?

  • Do All Tumors have Chromosome Abnormalities, and are such Changes Present only in Neoplastic Cells?

  • General Effects of Structural and Numerical Chromosome Abnormalities

  • At What Resolution Level are Neoplasia-Associated Mutations Best Studied?

  • Pathogenetic Versus Phenotypic Tumor Classification