2. Microdialysis in Drug Discovery

  1. Tung-Hu Tsai2,3
  1. Christian Höcht

Published Online: 25 JUL 2011

DOI: 10.1002/9781118011294.ch2

Applications of Microdialysis in Pharmaceutical Science

Applications of Microdialysis in Pharmaceutical Science

How to Cite

Höcht, C. (2011) Microdialysis in Drug Discovery, in Applications of Microdialysis in Pharmaceutical Science (ed T.-H. Tsai), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118011294.ch2

Editor Information

  1. 2

    National Yang-Ming University, Taipei, Taiwan

  2. 3

    Taipei City Hospital, Taipei, Taiwan

Author Information

  1. Instituto de Fisiopatología y Bioquímica Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina

Publication History

  1. Published Online: 25 JUL 2011
  2. Published Print: 5 AUG 2011

ISBN Information

Print ISBN: 9780470409282

Online ISBN: 9781118011294

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Keywords:

  • microdialysis in drug discovery, continuous monitoring - unbound extracellular concentrations at site of action;
  • role of pharmacokinetic–pharmacodynamic modeling in drug development - estimation of PK–PD parameters;
  • microdialysis sampling, an attractive approach - in early drug development of new chemical entities

Summary

This chapter contains sections titled:

  • Introduction

  • Phases of Drug Development

  • Role of Biomarkers in Drug Development

  • Role of Pharmacokinetic–Pharmacodynamic Modeling in Drug Development

  • Role of Microdialysis in Drug Development

  • Microdialysis Sampling in the Drug Development of Specific Therapeutic Groups

  • Regulatory Aspects of Microdialysis Sampling in Drug Development

  • Conclusions

  • References