6. Microdialysis as a Tool to Unravel Neurobiological Mechanisms of Seizures and Antiepileptic Drug Action

  1. Tung-Hu Tsai2,3
  1. Ilse Smolders,
  2. Ralph Clinckers and
  3. Yvette Michotte

Published Online: 25 JUL 2011

DOI: 10.1002/9781118011294.ch6

Applications of Microdialysis in Pharmaceutical Science

Applications of Microdialysis in Pharmaceutical Science

How to Cite

Smolders, I., Clinckers, R. and Michotte, Y. (2011) Microdialysis as a Tool to Unravel Neurobiological Mechanisms of Seizures and Antiepileptic Drug Action, in Applications of Microdialysis in Pharmaceutical Science (ed T.-H. Tsai), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118011294.ch6

Editor Information

  1. 2

    National Yang-Ming University, Taipei, Taiwan

  2. 3

    Taipei City Hospital, Taipei, Taiwan

Author Information

  1. Vrije Universiteit Brussels, Brussels, Belgium

Publication History

  1. Published Online: 25 JUL 2011
  2. Published Print: 5 AUG 2011

ISBN Information

Print ISBN: 9780470409282

Online ISBN: 9781118011294

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Keywords:

  • microdialysis as a tool, neurobiological mechanisms - of seizures and antiepileptic drug action;
  • microdialysis, electrical brain stimulation and neuronal circuits - in seizures, deep brain stimulation, a promising therapy for intractable epilepsy;
  • microdialysis, relationships between epilepsy and its comorbidities - microdialysis, interest-gaining neuro methods

Summary

This chapter contains sections titled:

  • Introduction

  • Microdialysis to Characterize Seizure-Related Neurobiological and Metabolic Changes in Animal Models and in Humans

  • Microdialysis as a Chemoconvulsant Delivery Tool in Animal Seizure Models

  • Microdialysis Used to Elucidate Mechanisms of Electrical Brain Stimulation and Neuronal Circuits Involved in Seizures

  • Microdialysis Used to Unravel the Mechanisms of Action of Established Antiepileptic Drugs and New Therapeutic Strategies

  • Microdialysis Studies in the Search for Mechanisms of Adverse Effects of Clinically Used Drugs, Drugs of Abuse, and Toxins

  • Combining Microdialysis with Other Complementary Neurotechniques to Unravel Mechanisms of Seizures and Epilepsy

  • The Advantage of Microdialysis Used to Sample Biophase Antiepileptic Drug Levels and to Monitor Neurotransmitters as Markers for Anticonvulsant Activity

  • Microdialysis Used to Study Relationships Between Epilepsy and Its Comorbidities

  • References