1. HIV Life Cycle: Targets for Anti-HIV Agents

  1. Nouri Neamati
  1. Erik De Clercq

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch1

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

De Clercq, E. (2011) HIV Life Cycle: Targets for Anti-HIV Agents, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch1

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • HIV life cycle, anti-HIV agent target;
  • virus–cell fusion;
  • viral capsid formation

Summary

This chapter contains sections titled:

  • Introduction: Overview of HIV Life Cycle

  • Virus Adsorption: Interaction of HIV with CD4 Receptor

  • Prelude to Fusion: Interaction of HIV with CXCR4 or CCR5 Coreceptor

  • Virus–Cell Fusion: Six-Helical Bundle Formation and Insertion of Fusion Peptide into Cell Membrane

  • From Viral RNA to Proviral DNA: Reverse Transcription

  • Integration of Proviral DNA into Host Cell Genome by HIV Integrase

  • HIV Transcription and Its Regulation (Activation)

  • Proteolytic Cleavage of Precursor into Mature Viral Proteins

  • Viral Capsid Formation: Ultimate Step to Block Virus Production?

  • Conclusion: Combination Therapy

  • Acknowledgment

  • References