10. Structural aspects of Lentiviral Integrase–LEDGF Interaction

  1. Nouri Neamati
  1. Stephen Hare1,
  2. Alan Engelman2,3 and
  3. Peter Cherepanov1

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch10

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Hare, S., Engelman, A. and Cherepanov, P. (2011) Structural aspects of Lentiviral Integrase–LEDGF Interaction, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch10

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Division of Medicine, Imperial College London, St.-Mary's Campus, London, United Kingdom

  2. 2

    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

  3. 3

    Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • lentiviral integrase–LEDGF interaction;
  • primary IN–LEDGF interface;
  • novel charge–charge interface

Summary

This chapter contains sections titled:

  • Introduction

  • Integrase Binding Domain (IBD) of LEDGF

  • Primary IN–LEDGF Interface

  • Role of Lentiviral IN N-Terminal Domain in High-Affinity Interaction with LEDGF

  • Conclusions

  • References