16. Conformationally Constrained Tricyclic HIV Integrase Inhibitors
- Nouri Neamati
Published Online: 28 SEP 2011
DOI: 10.1002/9781118015377.ch16
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
HIV-1 Integrase: Mechanism and Inhibitor Design
Additional Information
How to Cite
Fardis, M., Jin, H., Chen, X., Tsiang, M., Chen, J., Kim, C. and Wright, M. (2011) Conformationally Constrained Tricyclic HIV Integrase Inhibitors, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch16
Editor Information
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA
Publication History
- Published Online: 28 SEP 2011
- Published Print: 9 SEP 2011
ISBN Information
Print ISBN: 9780470184745
Online ISBN: 9781118015377
- Summary
- Chapter
- References
Keywords:
- tricyclic HIV integrase inhibitors;
- IN active site model;
- SAR of C-5-substituted tricyclic inhibitors
Summary
This chapter contains sections titled:
Introduction
Development of Integrase Active-Site Model to Aid Inhibitor Design
Integrase Structure
Developing Active-Site Model
The Tetramer Model
Molecular Modeling Summary
SAR of C-5-Substituted Tricyclic Inhibitors
Biological Characterization of GS-9160
Conclusion
References