17. Slow-Onset Kinetics of HIV Integrase Inhibitors and Proposed Molecular Model

  1. Nouri Neamati
  1. Edward P. Garvey1,† and
  2. Benjamin Schwartz2

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch17

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Garvey, E. P. and Schwartz, B. (2011) Slow-Onset Kinetics of HIV Integrase Inhibitors and Proposed Molecular Model, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch17

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Department of Virology, Infectious Disease Center for Excellence in Drug Discovery, GlaxoSmithKline, Research Triangle Park, North Carolina, USA

  2. 2

    Department of Biological Reagents and Assay Development, Molecular Discovery Research, GlaxoSmithKline, Upper Merion, Pennsylvania, USA

  1. Viamet Pharmaceuticals, Morrisville, North Carolina, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • HIV integrase inhibitors, slow-onset kinetics;
  • HIV integrase time-dependent inhibition;
  • model, INI slow-binding kinetics

Summary

This chapter contains sections titled:

  • Introduction

  • Time-Dependent Inhibition of HIV Integrase

  • Discussion and Model for INI Slow-Binding Kinetics

  • Conclusions and Future Studies

  • Acknowledgments

  • References