19. Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors
- Nouri Neamati
Published Online: 28 SEP 2011
DOI: 10.1002/9781118015377.ch19
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
HIV-1 Integrase: Mechanism and Inhibitor Design
Additional Information
How to Cite
Dicker, I. B., Walker, M. A., Lin, Z., Terry, B., Pajor, L., Zheng, M., Naidu, B. N., Banville, J., Meanwell, N. A. and Krystal, M. (2011) Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch19
Editor Information
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA
Publication History
- Published Online: 28 SEP 2011
- Published Print: 9 SEP 2011
ISBN Information
Print ISBN: 9780470184745
Online ISBN: 9781118015377
- Summary
- Chapter
- References
Keywords:
- HIV integrase inhibitor serum protein binding;
- protein binding effects;
- in vitro displacement assay
Summary
This chapter contains sections titled:
Introduction
Identification of Early Leads in Bristol-Myers Squibb (BMS) Discovery Program
Evaluating Protein Binding Effect on Integrase Inhibitors
Development of In Vitro Displacement Assay for Protein Binding Estimations
Conclusion
Experimental Methods
Acknowledgments
References