20. Role of Metals in HIV-1 Integrase Inhibitor Design
- Nouri Neamati
Published Online: 28 SEP 2011
DOI: 10.1002/9781118015377.ch20
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
HIV-1 Integrase: Mechanism and Inhibitor Design
Additional Information
How to Cite
Sechi, M., Carcelli, M., Rogolino, D. and Neamati, N. (2011) Role of Metals in HIV-1 Integrase Inhibitor Design, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch20
Editor Information
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA
Publication History
- Published Online: 28 SEP 2011
- Published Print: 9 SEP 2011
ISBN Information
Print ISBN: 9780470184745
Online ISBN: 9781118015377
- Summary
- Chapter
- References
Keywords:
- metals in HIV-1 integrase inhibitor design;
- metal cofactor catalytic role;
- two-metal binding model
Summary
This chapter contains sections titled:
Introduction
Catalytic Role of Metal Cofactors: Two-Metal-Ion Mechanism
Other Metal Ions on IN Enzyme
General Basis to Target Metal Ion Cofactors
β-Diketo Acids (DKAs): Important Class of IN Inhibitors as Example of Chelating Agents
Structural Studies of DKA Pharmacophoric Motif
Other Potential Metal Chelating Inhibitors
Studies of Chelating Ability for Several Pharmacophore Fragments
Two-Metal Binding as Strategy for IN Inhibitor Design: Recent Study
Two-Metal Binding Model as Potential General Inhibition Mechanism
From Ligands to Metal Complexes
Conclusions and Perspectives
Acknowledgments
Abbreviations
References