22. Development of Styrylquinoline Integrase Inhibitors

  1. Nouri Neamati
  1. Jean-François Mouscadet1,
  2. Eric Deprez1,
  3. Didier Desmaele2 and
  4. Jean D'Angelo2

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch22

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Mouscadet, J.-F., Deprez, E., Desmaele, D. and D'Angelo, J. (2011) Development of Styrylquinoline Integrase Inhibitors, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch22

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    LBPA, CNRS, Ecole Normale Supérieure de Cachan, Cachan, France

  2. 2

    Université Paris-Sud, Faculté de Pharmacie, CNRS, Châtenay-Malabry, France

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • styrylquinoline integrase inhibitors;
  • styrylquinolines, activity relationships;
  • cell culture antiviral activity

Summary

This chapter contains sections titled:

  • Introduction

  • Chemistry and Structure–Activity Relationships of Styrylquinolines In Vitro

  • Basis of Inhibitory Activity of Styrylquinolines In Vitro

  • Basis of Antiviral Activity in Cell Culture

  • Activity and Synergy of SQLs Against ARV-Resistant HIV-1 Strains

  • Further Development of Styrylquinolines

  • Acknowledgments

  • References