26. Computer-Aided Techniques in Design of HIV-1 Integrase Inhibitors

  1. Nouri Neamati
  1. Erik Serrao,
  2. Rambabu Gundla,
  3. Jinxia Deng,
  4. Srinivas Odde and
  5. Nouri Neamati

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch26

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Serrao, E., Gundla, R., Deng, J., Odde, S. and Neamati, N. (2011) Computer-Aided Techniques in Design of HIV-1 Integrase Inhibitors, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch26

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • computer-aided techniques, HIV-1 integrase;
  • receptor-based pharmacophore models;
  • QSAR-based models

Summary

This chapter contains sections titled:

  • Introduction

  • Analog-Based Molecular Modeling Studies

  • Receptor-Based Pharmacophore Models

  • QSAR-Based Models

  • Target Structure-Based Molecular Modeling Studies

  • Docking Studies with Surrogate Models

  • Recent Developments

  • Conclusions

  • References