27. Application of Protein Covalent Modification to Studying Structure and Function of HIV-1 Integrase and Its Inhibitors

  1. Nouri Neamati
  1. Xue Zhi Zhao and
  2. Terrence R. Burke Jr.

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch27

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Zhao, X. Z. and Burke, T. R. (2011) Application of Protein Covalent Modification to Studying Structure and Function of HIV-1 Integrase and Its Inhibitors, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch27

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute—Frederick, National Institutes of Health, Frederick, Maryland, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

SEARCH

Keywords:

  • protein covalent modification;
  • oligomeric forms, of recombinant IN;
  • diketo acid–based compounds

Summary

This chapter contains sections titled:

  • Introduction

  • Covalent Modification Using Substrate Nucleotides

  • Direct Cross-Linking of IN Protein

  • Covalent Modification by Inhibitors of IN Function

  • Conclusions

  • Acknowledgments

  • References