29. New Paradigm for Integrase Inhibition: Blocking Enzyme Function without Directly Targeting the Active Site

  1. Nouri Neamati
  1. Laith Q. Al-Mawsawi and
  2. Nouri Neamati

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch29

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Al-Mawsawi, L. Q. and Neamati, N. (2011) New Paradigm for Integrase Inhibition: Blocking Enzyme Function without Directly Targeting the Active Site, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch29

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • new paradigm for integrase inhibition;
  • blocking enzyme function;
  • allosteric inhibitory approach

Summary

This chapter contains sections titled:

  • Introduction

  • Allosteric Binding Concept

  • Allosteric Inhibitors and HIV-1

  • Basis for IN Allosteric Drug Development

  • N-Terminal Domain

  • Disrupting in Oligomers as Allosteric Inhibitory Approach

  • IN Cellular Cofactor Interaction Regions as Allosteric Inhibitor Binding Sites

  • Nucleotide-Based Inhibitor Binding Sites

  • Conclusions

  • References