29. New Paradigm for Integrase Inhibition: Blocking Enzyme Function without Directly Targeting the Active Site
- Nouri Neamati
Published Online: 28 SEP 2011
DOI: 10.1002/9781118015377.ch29
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
HIV-1 Integrase: Mechanism and Inhibitor Design
Additional Information
How to Cite
Al-Mawsawi, L. Q. and Neamati, N. (2011) New Paradigm for Integrase Inhibition: Blocking Enzyme Function without Directly Targeting the Active Site, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch29
Editor Information
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA
Publication History
- Published Online: 28 SEP 2011
- Published Print: 9 SEP 2011
ISBN Information
Print ISBN: 9780470184745
Online ISBN: 9781118015377
- Summary
- Chapter
- References
Keywords:
- new paradigm for integrase inhibition;
- blocking enzyme function;
- allosteric inhibitory approach
Summary
This chapter contains sections titled:
Introduction
Allosteric Binding Concept
Allosteric Inhibitors and HIV-1
Basis for IN Allosteric Drug Development
N-Terminal Domain
Disrupting in Oligomers as Allosteric Inhibitory Approach
IN Cellular Cofactor Interaction Regions as Allosteric Inhibitor Binding Sites
Nucleotide-Based Inhibitor Binding Sites
Conclusions
References