3. Integrase Mechanism and Function

  1. Nouri Neamati
  1. Robert Craigie

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch3

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Craigie, R. (2011) Integrase Mechanism and Function, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch3

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377



  • integrase mechanism and function;
  • retroviral DNA integration integrase;
  • retroviral DNA integration


This chapter contains sections titled:

  • Introduction

  • Discovery of Retroviral Integrase and Early Biochemical Studies

  • HIV-1 Integrase

  • DNA Cutting and Joining Steps of Retroviral DNA Integration

  • Mechanistic Similarity to DNA Transposition and Structural Similarity of Catalytic Domain of Integrase to Other Polynucleotidyl Transferases

  • In Vitro Activities of Retroviral Integrases

  • Two-Metal-Ion Mechanism of Catalysis

  • Nucleoprotein Intermediates in HIV-1 DNA Integration

  • Unanswered Questions Related to Mechanism of HIV-1 DNA Integration

  • Note

  • Acknowledgments

  • References