30. Resistance to Inhibitors of HIV-1 Integrase

  1. Nouri Neamati
  1. Anneleen Hombrouck1,
  2. Reginald Clayton1,
  3. Arnout Voet2,
  4. Myriam Witvrouw3,5 and
  5. Zeger Debyser4,5

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch30

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Hombrouck, A., Clayton, R., Voet, A., Witvrouw, M. and Debyser, Z. (2011) Resistance to Inhibitors of HIV-1 Integrase, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch30

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Tibotec BVBA, Generaal de Wittelaan, Mechelen, Belgium

  2. 2

    The Laboratory for Biomolecular Modelling, Katholieke Universiteit Leuven, Leuven, Belgium

  3. 3

    Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium

  4. 4

    Laboratory of Molecular Virology and Gene Therapy, and Division of Molecular Medicine, Katholieke Universiteit Leuven, Flauders, Belgium

  5. 5

    IRC Katholieke Universiteit Leuven Campus Kortrijk, Belgium

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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Keywords:

  • HIV-1 integrase inhibitor resistance;
  • viral resistance;
  • INSTIs and Mg2+ binding motifs

Summary

This chapter contains sections titled:

  • Introduction

  • Viral Resistance

  • Viral Resistance Against IN Strand Transfer Inhibitors

  • Viral Resistance Studies with Different Mode of Action INIs in Early Preclinical Development

  • Discussion and General Conclusions

  • References