4. Structural Studies of Retroviral Integrases

  1. Nouri Neamati
  1. Mariusz Jaskolski1,2,
  2. Jerry N. Alexandratos3,
  3. Grzegorz Bujacz2,4 and
  4. Alexander Wlodawer3

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch4

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Jaskolski, M., Alexandratos, J. N., Bujacz, G. and Wlodawer, A. (2011) Structural Studies of Retroviral Integrases, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch4

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland

  2. 2

    Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

  3. 3

    Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, USA

  4. 4

    Institute of Technical Biochemistry, Technical University of Lodz, Lodz, Poland

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377



  • retroviral integrases;
  • integrase catalytic domain;
  • C-terminal domain of integrase


This chapter contains sections titled:

  • Introduction

  • Amino Acid Sequence and Domain Structure of Retroviral Integrases

  • Crystallization of Integrase

  • Catalytic Domain of Integrase

  • N-Terminal Domain of Integrase

  • C-Terminal Domain of Integrase

  • Two-Domain Constructs Consisting of N and Cat Domains

  • Two-Domain Constructs Consisting of Cat and C Domains

  • Oligomeric States of Full-Length Integrase and Modeling of Its Structure

  • Structural Studies of Inhibitor Complexes of Integrase

  • Structural Basis of Enzymatic Activity of Integrase

  • Concluding Remarks

  • Acknowledgment

  • References