4. Structural Studies of Retroviral Integrases
- Nouri Neamati
Published Online: 28 SEP 2011
DOI: 10.1002/9781118015377.ch4
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
HIV-1 Integrase: Mechanism and Inhibitor Design
Additional Information
How to Cite
Jaskolski, M., Alexandratos, J. N., Bujacz, G. and Wlodawer, A. (2011) Structural Studies of Retroviral Integrases, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch4
Editor Information
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA
Publication History
- Published Online: 28 SEP 2011
- Published Print: 9 SEP 2011
ISBN Information
Print ISBN: 9780470184745
Online ISBN: 9781118015377
- Summary
- Chapter
- References
Keywords:
- retroviral integrases;
- integrase catalytic domain;
- C-terminal domain of integrase
Summary
This chapter contains sections titled:
Introduction
Amino Acid Sequence and Domain Structure of Retroviral Integrases
Crystallization of Integrase
Catalytic Domain of Integrase
N-Terminal Domain of Integrase
C-Terminal Domain of Integrase
Two-Domain Constructs Consisting of N and Cat Domains
Two-Domain Constructs Consisting of Cat and C Domains
Oligomeric States of Full-Length Integrase and Modeling of Its Structure
Structural Studies of Inhibitor Complexes of Integrase
Structural Basis of Enzymatic Activity of Integrase
Concluding Remarks
Acknowledgment
References