5. Retroviral Integration Target Site Selection

  1. Nouri Neamati
  1. Angela Ciuffi1 and
  2. Frederic Bushman2

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch5

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Ciuffi, A. and Bushman, F. (2011) Retroviral Integration Target Site Selection, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch5

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Institute of Microbiology (IMUL), University Hospital Center and University of Lausanne, Lausanne, Switzerland

  2. 2

    University of Pennsylvania School of Medicine, Department of Microbiology, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377



  • retroviral integration target site selection;
  • chromatin accessibility model;
  • retroviral integration, gene therapy


This chapter contains sections titled:

  • Summary

  • Introduction: Retroviral Integration

  • Integration Mechanism

  • Chromatin Accessibility Model

  • Cell Cycle Model

  • Tethering Model

  • Retroviral Integration and Gene Therapy

  • Conclusions/Perspectives

  • Acknowledgments

  • References