7. Insights into HIV-1 Integrase–DNA Interactions

  1. Nouri Neamati
  1. Allison Johnson1,
  2. Christophe Marchand2 and
  3. Yves Pommier2

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch7

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

How to Cite

Johnson, A., Marchand, C. and Pommier, Y. (2011) Insights into HIV-1 Integrase–DNA Interactions, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch7

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. 1

    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, USA

  2. 2

    National Cancer Institute, Bethesda, Maryland, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377



  • HIV-1 integrase–DNA interactions;
  • HIV LTR DNA backbone in IN reactions;
  • IN, DNA, magnesium ion role


This chapter contains sections titled:

  • Introduction

  • Role of HIV LTR DNA Backbone in IN Reactions

  • HIV LTR DNA Minor-Groove Interactions

  • HIV LTR DNA Major-Groove Interactions

  • Interaction Between HIV LTR Cytosine and IN Gln148 Is Required for Strand Transfer

  • General HIV LTR Binding by IN

  • Structural Features of HIV LTR Enabling Sequence-Specific Binding by IN

  • IN Amino Acids in Specific Contact with Viral LTR Bases

  • Model of Interactions Between IN/Magnesium/Viral LTR Following 3′ Processing

  • IN Interactions with Inhibitors

  • References