8. Functional Interaction between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase

  1. Nouri Neamati
  1. Thomas A. Wilkinson,
  2. Samson A. Chow

Published Online: 28 SEP 2011

DOI: 10.1002/9781118015377.ch8

Book Title

HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

Additional Information

How to Cite

Wilkinson, T. A. and Chow, S. A. (2011) Functional Interaction between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase, in HIV-1 Integrase: Mechanism and Inhibitor Design (ed N. Neamati), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015377.ch8

Editor Information

  1. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, California, USA

Author Information

  1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA

Publication History

  1. Published Online: 28 SEP 2011
  2. Published Print: 9 SEP 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470184745

Online ISBN: 9781118015377

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CHAPTER TOOLS

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Keywords:

  • HIV Type 1 reverse transcriptase, integrase;
  • IN–RT interactions in vitro;
  • molecular mechanisms

Summary

This chapter contains sections titled:

  • Introduction

  • Reverse Transcription

  • Genetic Evidence for Effect of IN on Reverse Transcription

  • IN–RT Interactions In Vitro

  • Functional Role of IN–RT Interactions

  • Molecular Mechanisms

  • Conclusions

  • References

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