16. Intermediate Filaments

  1. Ivan R. Nabi
  1. Normand Marceau,
  2. Anne Loranger,
  3. Stéphane Gilbert and
  4. François Bordeleau

Published Online: 31 MAY 2011

DOI: 10.1002/9781118015759.ch16

Cellular Domains

Cellular Domains

How to Cite

Marceau, N., Loranger, A., Gilbert, S. and Bordeleau, F. (2011) Intermediate Filaments, in Cellular Domains (ed I. R. Nabi), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015759.ch16

Editor Information

  1. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, British Columbia, Canada

Author Information

  1. Centre de recherche en cancérologie de l'UniversitéLaval and Centre de Recherche du Centre Hospitalier de Québec (CRCHUQ), Quebec City, Quebec, Canada

Publication History

  1. Published Online: 31 MAY 2011
  2. Published Print: 1 AUG 2011

ISBN Information

Print ISBN: 9780470595442

Online ISBN: 9781118015759



  • intermediate filaments (IFs), actin microfilaments - cytoskeleton, in nucleated eukaryotic cells;
  • Ifs, as multiple gene family of proteins - IF proteins, six, with key features of cells of origin;
  • keratin Ifs, and viscoelastic properties - resistant to cell deformation, other mechanical stresses


This chapter contains sections titled:

  • Definition

  • Historical Perspective

  • Key If Protein Features

  • Keratin Interplay with Surface Membrane Domains

  • Relevance to Human Diseases

  • Uncertainties and Controversies

  • Future Perspectives

  • Acknowledgments

  • Abbreviations

  • References