17. Focal Adhesions

  1. Ivan R. Nabi
  1. Caitlin Tolbert1 and
  2. Keith Burridge2

Published Online: 31 MAY 2011

DOI: 10.1002/9781118015759.ch17

Cellular Domains

Cellular Domains

How to Cite

Tolbert, C. and Burridge, K. (2011) Focal Adhesions, in Cellular Domains (ed I. R. Nabi), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015759.ch17

Editor Information

  1. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, British Columbia, Canada

Author Information

  1. 1

    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA

  2. 2

    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA

Publication History

  1. Published Online: 31 MAY 2011
  2. Published Print: 1 AUG 2011

ISBN Information

Print ISBN: 9780470595442

Online ISBN: 9781118015759

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Keywords:

  • adhesive and communicating domains - focal adhesions (FAs), integrins mediating adhesion;
  • FA complexity, proteins - structural role, most involved in signaling cascades;
  • Rho GTPase cycle, and Rho proteins cycle - GTP-bound active state and GDP-bound inactive state

Summary

This chapter contains sections titled:

  • Definition

  • Historical Perspective

  • Assembly of FCXS and FAS

  • FA Complexity

  • Mechanisms of FA and FCX Disassembly

  • Imaging Adhesion Dynamics

  • Future Perspectives

  • Abbreviations

  • References