15. Biocompatible Polymers for Nucleic Acid Delivery

  1. Abraham J. Domb2,
  2. Neeraj Kumar3 and
  3. Aviva Ezra2
  1. Jeff Sparks and
  2. Khursheed Anwer

Published Online: 3 MAY 2011

DOI: 10.1002/9781118015810.ch15

Biodegradable Polymers in Clinical Use and Clinical Development

Biodegradable Polymers in Clinical Use and Clinical Development

How to Cite

Sparks, J. and Anwer, K. (2011) Biocompatible Polymers for Nucleic Acid Delivery, in Biodegradable Polymers in Clinical Use and Clinical Development (eds A. J. Domb, N. Kumar and A. Ezra), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118015810.ch15

Editor Information

  1. 2

    Institute for Drug Design, Medicinal Chemistry, School of Pharmacy – Faculty of Medicine, The Hebrew University, Jerusalem, Israel

  2. 3

    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India

Author Information

  1. EGEN, Inc., Huntsville, Alabama, USA

Publication History

  1. Published Online: 3 MAY 2011
  2. Published Print: 20 JUN 2011

ISBN Information

Print ISBN: 9780470424759

Online ISBN: 9781118015810

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Keywords:

  • biodegradable polymers, emerging clinical uses - biocompatible polymers for nucleic acid delivery and delivery polymers;
  • PEI polyplex encapsulation - microspheres to achieve favorable DNA release kinetic;
  • synthetic noncondensing polymers, nucleic acid delivery to skeletal muscle - valuable therapeutic application

Summary

This chapter contains sections titled:

  • Introduction

  • Cationic Polymers

  • Synthetic Noncondensing Polymers

  • siRNA Delivery Polymers

  • Clinical Development of Polymeric Delivery Systems

  • References

  • Bibliography