15. Effect of Buffers and Stabilizers on Vaccine Stability and Efficacy

  1. Manmohan Singh and
  2. Indresh K. Srivastava
  1. Shireesh P. Apte1 and
  2. Sydney O. Ugwu2

Published Online: 6 JUN 2011

DOI: 10.1002/9781118023648.ch15

Development of Vaccines: From Discovery to Clinical Testing

Development of Vaccines: From Discovery to Clinical Testing

How to Cite

Apte, S. P. and Ugwu, S. O. (2011) Effect of Buffers and Stabilizers on Vaccine Stability and Efficacy, in Development of Vaccines: From Discovery to Clinical Testing (eds M. Singh and I. K. Srivastava), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118023648.ch15

Editor Information

  1. Novartis Vaccines, Cambridge, Massachusetts, USA

Author Information

  1. 1

    Mansfield, Texas, USA

  2. 2

    Pfizer Vaccine Research, Pearl River, New York, USA

Publication History

  1. Published Online: 6 JUN 2011
  2. Published Print: 18 JUL 2011

ISBN Information

Print ISBN: 9780470256374

Online ISBN: 9781118023648

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Keywords:

  • buffer and stabilizer effect - on vaccine stability and efficacy;
  • excipient effect on vaccine efficacy - buffer effects, on protein conformational stability;
  • polymeric zwitterionic (ZPS) buffers - CD4+ T-cell responses, positively and negatively charged

Summary

This chapter contains sections titled:

  • Mechanisms of Stabilization of Vaccines by Buffers/Stabilizers

  • Effect of Excipients on Vaccine Efficacy

  • Surfactant Effects

  • Antioxidant Effects

  • Preservative Effects

  • Sugars

  • Amino and Nucleic Acids

  • Chelating Agent

  • Polymeric Zwitterionic Buffers

  • Abbreviations

  • References