8. DNA Vaccines for Infectious Diesase

  1. Manmohan Singh and
  2. Indresh K. Srivastava
  1. Samuel Stepenson1,
  2. Manmohan Singh2 and
  3. Indresh K. Srivastava2

Published Online: 6 JUN 2011

DOI: 10.1002/9781118023648.ch8

Development of Vaccines: From Discovery to Clinical Testing

Development of Vaccines: From Discovery to Clinical Testing

How to Cite

Stepenson, S., Singh, M. and Srivastava, I. K. (2011) DNA Vaccines for Infectious Diesase, in Development of Vaccines: From Discovery to Clinical Testing (eds M. Singh and I. K. Srivastava), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118023648.ch8

Editor Information

  1. Novartis Vaccines, Cambridge, Massachusetts, USA

Author Information

  1. 1

    Novartis Vaccines, Siena, Italy

  2. 2

    Novartis Vaccines, Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 6 JUN 2011
  2. Published Print: 18 JUL 2011

ISBN Information

Print ISBN: 9780470256374

Online ISBN: 9781118023648

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Keywords:

  • DNA vaccines for infectious disease - and vector and gene optimization;
  • inherent immunostimulatory activity of bacterial DNA - of DNA-based adjuvants for proteins;
  • live viral and bacterial vectors, vaccine delivery - attenuated SIV, AIDS-like disease in monkeys

Summary

This chapter contains sections titled:

  • Introduction

  • Humoral Immune Responses

  • Cytotoxic T-Cell Responses

  • Protection by DNA Vaccines in Preclinical Disease Models

  • Vector and Gene Optimization

  • Adjuvants for DNA Vaccines

  • Immunostimulatory Activity of DNA Vaccines

  • DNA Vaccine Delivery Systems

  • Physical Methods

  • Particle-Mediated Delivery of DNA Vaccines

  • Use of Live Viral and Bacterial Vectors for Vaccine Delivery

  • Summary

  • References