12. Whole Cell Production of Fine Chemicals and Intermediates

  1. Junhua (Alex) Tao3 and
  2. Romas Kazlauskas4
  1. Karen Robins1 and
  2. John Gordon2

Published Online: 12 APR 2011

DOI: 10.1002/9781118028308.ch12

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development

How to Cite

Robins, K. and Gordon, J. (2011) Whole Cell Production of Fine Chemicals and Intermediates, in Biocatalysis for Green Chemistry and Chemical Process Development (eds J. (. Tao and R. Kazlauskas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118028308.ch12

Editor Information

  1. 3

    Institute of Sustainability, Hangzhou Normal University, Hangzhou, China

  2. 4

    Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA

Author Information

  1. 1

    Lonza AG, Switzerland

  2. 2

    LES R&D Evaluations and Business Process Excellence, Lonza AG, Visp., Switzerland

Publication History

  1. Published Online: 12 APR 2011
  2. Published Print: 6 JUN 2011

ISBN Information

Print ISBN: 9780470437780

Online ISBN: 9781118028308

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Keywords:

  • whole cell production of fine chemicals and intermediates;
  • (S)-(-)-2,2-Dimethylcyclopropane carboxamide - a chiral intermediate for cilastatin production, a renal dehydropeptidase inhibitor;
  • regiospecifically hydroxy-substituted aromatic N-heterocyclic carboxylic acids - enabling effective synthesis, intermediates for pharmaceutical synthesis

Summary

This chapter contains sections titled:

  • Introduction

  • L-Carnitine

  • Nicotinamide

  • (S)-(-)-2,2-Dimethylcyclopropane Carboxamide

  • Regiospecific Hydroxylation of Heterocyclic Carboxylic Acids

  • Methyl and Ethyl Group Oxidation of Aromatic Heterocycles

  • Ethyl (R)-4-Cyano-3-Hydroxybutyrate

  • Conclusion

  • Acknowledgment

  • References