5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs

  1. Junhua (Alex) Tao2 and
  2. Romas Kazlauskas3
  1. Ramesh N. Patel

Published Online: 12 APR 2011

DOI: 10.1002/9781118028308.ch5

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development

How to Cite

Patel, R. N. (2011) Biocatalytic Routes to Chiral Intermediates for Development of Drugs, in Biocatalysis for Green Chemistry and Chemical Process Development (eds J. (. Tao and R. Kazlauskas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118028308.ch5

Editor Information

  1. 2

    Institute of Sustainability, Hangzhou Normal University, Hangzhou, China

  2. 3

    Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA

Author Information

  1. SLRP Associates, Biotechnology Consultation, Bridgewater, NJ, USA

Publication History

  1. Published Online: 12 APR 2011
  2. Published Print: 6 JUN 2011

ISBN Information

Print ISBN: 9780470437780

Online ISBN: 9781118028308

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Keywords:

  • applications, pharmaceuticals and fine chemicals - biocatalytic routes to chiral intermediates for drug development;
  • enzymatic desymmetrization process - in biological processes, pain transmission, inflammation, vasodialation and secretion;
  • enzyme-mediated Baeyer–Villiger oxidation - “green chemistry” approach for chiral lactone production

Summary

This chapter contains sections titled:

  • Introduction

  • Enzymatic Preparation of Chiral Unnatural Amino Acids

  • Enzymatic Desymmetrization Process

  • Enzymatic Hydroxylation

  • Enzymatic Reduction Process

  • Microbial Baeyer-Villiger Oxidations

  • Enzymatic Condensation Reactions

  • Enantioselective Enzymatic Acylation

  • Dynamic Kinetic Resolution (DKR)

  • Conclusions

  • References