6. Transglutaminase for Protein Drug Modification: Pegylation and beyond

  1. Junhua (Alex) Tao3 and
  2. Romas Kazlauskas4
  1. Sean Hu1 and
  2. Yifeng Yin2

Published Online: 12 APR 2011

DOI: 10.1002/9781118028308.ch6

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development

How to Cite

Hu, S. and Yin, Y. (2011) Transglutaminase for Protein Drug Modification: Pegylation and beyond, in Biocatalysis for Green Chemistry and Chemical Process Development (eds J. (. Tao and R. Kazlauskas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118028308.ch6

Editor Information

  1. 3

    Institute of Sustainability, Hangzhou Normal University, Hangzhou, China

  2. 4

    Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA

Author Information

  1. 1

    Novozymes, Davis, CA, USA

  2. 2

    Trinity Biosystems, Inc., Menlo Park, CA, USA

Publication History

  1. Published Online: 12 APR 2011
  2. Published Print: 6 JUN 2011

ISBN Information

Print ISBN: 9780470437780

Online ISBN: 9781118028308

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Keywords:

  • transglutaminase for protein drug modification - pegylation and beyond;
  • tailor-made mTGase for protein drug site-specific modification - chemicals, of given protein at specific site, challenging and impossible;
  • PEGylation emerging, as the most successful method - extending half-life and minimizing immunogenicity

Summary

This chapter contains sections titled:

  • Introduction

  • Chemical Conjugation of PEG

  • Tailor-Made mTGase for Site-Specific Modification of Protein Drugs

  • Conclusion

  • References