7. Microbial Production of Plant-Derived Pharmaceutical Natural Products through Metabolic Engineering: Artemisinin and beyond

  1. Junhua (Alex) Tao4 and
  2. Romas Kazlauskas5
  1. Jeffrey A. Dietrich1,
  2. J. L. Fortman3,
  3. Darmawi Juminaga2 and
  4. Jay D. Keasling3

Published Online: 12 APR 2011

DOI: 10.1002/9781118028308.ch7

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development

How to Cite

Dietrich, J. A., Fortman, J. L., Juminaga, D. and Keasling, J. D. (2011) Microbial Production of Plant-Derived Pharmaceutical Natural Products through Metabolic Engineering: Artemisinin and beyond, in Biocatalysis for Green Chemistry and Chemical Process Development (eds J. (. Tao and R. Kazlauskas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118028308.ch7

Editor Information

  1. 4

    Institute of Sustainability, Hangzhou Normal University, Hangzhou, China

  2. 5

    Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA

Author Information

  1. 1

    UCB-UCSF Joint Graduate Group in Bioengineering, UC-Berkeley, UC-San Francisco, Berkeley, CA, USA

  2. 2

    California Institute of Quantitative Biomedical Research (QB3), University of California-Berkeley, Berkeley, CA, USA

  3. 3

    Fuels Synthesis Division, Joint BioEnergy Institute, Lawrence Berkeley, National Laboratory, Berkeley, CA, USA

Publication History

  1. Published Online: 12 APR 2011
  2. Published Print: 6 JUN 2011

ISBN Information

Print ISBN: 9780470437780

Online ISBN: 9781118028308

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Keywords:

  • microbial production of plant-derived pharmaceutical natural products - through metabolic engineering, artemisinin and beyond;
  • gene copy numbers of titrating pathway enzymes - identifying mevalonate kinase (MK), as the rate-limiting pathway enzyme for amorphadiene biosynthesis;
  • terpene indole alkaloids - expanding upon mevalonate pathway

Summary

This chapter contains sections titled:

  • The Case for Microbial Production of Plant-Derived Pharmaceuticals

  • Using Artemisinin to Establish an Isoprenoid Biosynthesis Platform

  • Terpene Indole Alkaloids: Expanding upon the Mevalonate Pathway

  • Benzylisoquinoline Alkaloids (BIAs): Revisiting Plant-Derived Enzyme Overexpression

  • Conclusions

  • References