3. Chaperone-Mediated Autophagy and Parkinson's Disease

  1. Stephan N. Witt
  1. Marta Martinez-Vicente1 and
  2. Ester Wong2

Published Online: 6 JUN 2011

DOI: 10.1002/9781118063903.ch3

Protein Chaperones and Protection from Neurodegenerative Diseases

Protein Chaperones and Protection from Neurodegenerative Diseases

How to Cite

Martinez-Vicente, M. and Wong, E. (2011) Chaperone-Mediated Autophagy and Parkinson's Disease, in Protein Chaperones and Protection from Neurodegenerative Diseases (ed S. N. Witt), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118063903.ch3

Editor Information

  1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway Shreveport, LA 71130-3932, USA

Author Information

  1. 1

    Vall d'Hebron Research Insititue, Barcelona, Spain

  2. 2

    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin B.504, Bronx, NY 10461, USA

Publication History

  1. Published Online: 6 JUN 2011
  2. Published Print: 1 AUG 2011

Book Series:

  1. Wiley Series on Protein and Peptide Science

Book Series Editors:

  1. Vladimir N. Uversky

ISBN Information

Print ISBN: 9780470569078

Online ISBN: 9781118063903



  • chaperone-mediated autophagy and Parkinson's disease - protein homeostasis, and neurodegeneration;
  • autophagy in neurodegeneration - cell basal macroautophagy, as neurons and myocytes;
  • protein misfolding, aggregation and dysfunction - intracellular surveillance systems, PD pathogenesis


This chapter contains sections titled:

  • Protein Homeostasis and Neurodegeneration

  • Failure of Cellular Quality Control in the PD Brain

  • Different Flavors of Autophagy: Mechanisms and Functions

  • Autophagy in Neurodegeneration

  • Nuts and Bolts of Chaperone-Mediated Autophagy

  • Physiological Roles of CMA

  • Impairment of CMA in PD

  • Cellular Consequences of CMA Blockage and Therapeutic Implications

  • Concluding Remarks

  • Acknowledgment

  • References