30. Uncontrolled Clinical Trials

  1. Bradley E. Huitema

Published Online: 14 OCT 2011

DOI: 10.1002/9781118067475.ch30

The Analysis of Covariance and Alternatives: Statistical Methods for Experiments, Quasi-Experiments, and Single-Case Studies, Second Edition

The Analysis of Covariance and Alternatives: Statistical Methods for Experiments, Quasi-Experiments, and Single-Case Studies, Second Edition

How to Cite

Huitema, B. E. (2011) Uncontrolled Clinical Trials, in The Analysis of Covariance and Alternatives: Statistical Methods for Experiments, Quasi-Experiments, and Single-Case Studies, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067475.ch30

Author Information

  1. Department of Psychology, Western Michigan University, Kalamazoo, Michigan, USA

Publication History

  1. Published Online: 14 OCT 2011
  2. Published Print: 14 OCT 2011

Book Series:

  1. Wiley Series in Probability and Statistics

Book Series Editors:

  1. Walter A. Shewhart and
  2. Samuel S. Wilks

ISBN Information

Print ISBN: 9780471748960

Online ISBN: 9781118067475

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Keywords:

  • internal validity threats;
  • Naranjo–McKean dual effects model;
  • regression effects;
  • uncontrolled clinical trial

Summary

Many medical researchers label it as an uncontrolled clinical trial, a clinical trial, a before–after design, a screening design, or an intervention study. The difference between the pretest and posttest sample means is the basic descriptive measure of the study outcome. If the sampling method is known to be of a simple form it is possible to identify an analysis that will correct for regression artifacts, but such an analysis is relevant only if design threats that are common with this design can be ruled out. Ruling out design threats involves the collection of data that are external to the experiment. The most adequate analytic approach appears to be the Naranjo–McKean dual effects model; it corrects for regression artifacts and provides both additive and multiplicative effect estimates. The Naranjo–McKean (2001) dual effects model includes parameters required for a comprehensive description of the characteristics of one-group pretest–posttest data.

Controlled Vocabulary Terms

regression