10. Liver Drug Metabolism

  1. Ming Hu2 and
  2. Xiaoling Li3
  1. Leslie M. Tompkins and
  2. Hongbing Wang

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch10

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Tompkins, L. M. and Wang, H. (2011) Liver Drug Metabolism, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch10

Editor Information

  1. 2

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 3

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • liver drug metabolism, mechanisms - pharmaceutical drug metabolism, hurdles to drug bioavailability;
  • phase II drug metabolism - phase I and phase II, linear progression of metabolism for compounds;
  • adverse drug reactions (ADRs), genetic polymorphisms - concerns of pharmaceutics

Summary

This chapter contains sections titled:

  • Introduction

  • Hepatic structure and function

  • Phase I drug metabolism

  • Phase II drug metabolism

  • Current perspective on drug metabolism

  • Conclusion

  • References