13. Pharmacokinetic Behaviors of Orally Administered Drugs

  1. Ming Hu5 and
  2. Xiaoling Li6
  1. Jaime A. Yáñez1,
  2. Dion R. Brocks2,
  3. Laird M. Forrest3 and
  4. Neal M. Davies4

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch13

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Yáñez, J. A., Brocks, D. R., Forrest, L. M. and Davies, N. M. (2011) Pharmacokinetic Behaviors of Orally Administered Drugs, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch13

Editor Information

  1. 5

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 6

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Department of Drug Metabolism and Pharmacokinetics (DMPK), Alcon Laboratories, Inc., 6201 S. Freeway, Fort Worth, TX 76134, USA

  2. 2

    Faculty of Pharmacy, University of Alberta, Alberta, Canada

  3. 3

    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA

  4. 4

    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • pharmacokinetic behaviors of orally administered drugs - temporal and spatial drug disposition;
  • physiologically based pharmacokinetic (PBPK) model - compartments, and drug distribution;
  • physiological factors, affecting oral concentration - time profiles, metabolite rate of change

Summary

This chapter contains sections titled:

  • Introduction

  • Physicochemical factors affecting oral concentration–time profiles

  • Physiological factors affecting oral concentration–time profiles

  • Food effects and oral concentration–time profiles

  • Summation

  • Abbreviations

  • References