16. Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans

  1. Ming Hu4 and
  2. Xiaoling Li5
  1. Ayman El-Kattan1,
  2. Susan Hurst1,
  3. Joanne Brodfuehrer2 and
  4. Cho-Ming Loi3

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch16

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

El-Kattan, A., Hurst, S., Brodfuehrer, J. and Loi, C.-M. (2011) Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch16

Editor Information

  1. 4

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 5

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, CT, USA

  2. 2

    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Cambridge, MA, USA

  3. 3

    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

SEARCH

Keywords:

  • anatomical and physiological factors, oral drug bioavailability - rats, humans, new chemical entity (NCE);
  • gastrointestinal pH, ionization extent - drug dissolution rate, GI tract passive permeability;
  • oral bioavailability, in success of NCEs - interplay of physicochemical property of compounds

Summary

This chapter contains sections titled:

  • Introduction

  • Determinants of oral bioavailability

  • Summary

  • References