18. Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals

  1. Ming Hu6 and
  2. Xiaoling Li7
  1. David J. Lindley1,
  2. Stephen M. Carl1,
  3. Dea Herrera-Ruiz2,
  4. Li F. Pan1,
  5. Lori B. Karpes1,
  6. Jonathan M. E. Goole3,
  7. Olafur S. Gudmundsson4 and
  8. Gregory T. Knipp5

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch18

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Lindley, D. J., Carl, S. M., Herrera-Ruiz, D., Pan, L. F., Karpes, L. B., Goole, J. M. E., Gudmundsson, O. S. and Knipp, G. T. (2011) Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch18

Editor Information

  1. 6

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 7

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Department Industrial and Physical Pharmacy, College of Pharmacy, Nursing and Health Sciences, Purdue University, West Lafayette, IN 47907, USA

  2. 2

    Universidad Aut′onoma del Estado de Morelos, Facultad de Farmacia, Cuernavaca, Mexico

  3. 3

    Laboratory of Pharmaceutics and Biopharmaceutics, Universite Libre de Bruxelles, Institute of Pharmacy, 1050 Brussels, Beligum

  4. 4

    Discovery Pharmaceutics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, NJ, USA

  5. 5

    Department Industrial and Physical Pharmacy, College of Pharmacy, Nursing and Health Sciences, Purdue University, 575 Stadium Mall Dr., Room 308A, West Lafayette, IN 47907–2091, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • drug transporters, absorption - peptides and peptide-based pharmaceuticals, predicting ADMET;
  • transport systems, peptide-based absorption - solute carrier (SLC) family, ATP-Binding Cassette (ABC) transporters;
  • identifying molecular requirements of compounds - targeting drugs, formulation design

Summary

This chapter contains sections titled:

  • Introduction

  • Transport systems mediating peptide-based pharmaceutical absorption and disposition

  • Gastrointestinal-tract-specific transporter activity

  • In vitro/In vivo case studies: utilizing transport systems for drug delivery

  • Conclusions

  • Acknowledgments

  • References