24. ABC Transporters in Intestinal and Liver Efflux

  1. Ming Hu2 and
  2. Xiaoling Li3
  1. Marilyn E. Morris and
  2. Yash A. Gandhi

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch24

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Morris, M. E. and Gandhi, Y. A. (2011) ABC Transporters in Intestinal and Liver Efflux, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch24

Editor Information

  1. 2

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 3

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, NY, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • ABC transporters in intestinal and liver efflux - oral bioavailability, xenobiotics disposition;
  • basolateral/lateral membrane efflux proteins - ABCC1 (MRP1);
  • ABC family of efflux transporters, absorption - xenobiotics hepatobiliary transport

Summary

This chapter contains sections titled:

  • Introduction

  • Apical membrane efflux proteins

  • Basolateral/lateral membrane efflux proteins

  • Clinical relevance of ABC transporters in oral bioavailability of drugs

  • Pharmacogenomics of ABC transporters

  • Coordinate regulation of drug-metabolizing enzymes and efflux transporters

  • Summary

  • Abbreviations

  • References