25. Interplay between Efflux Transporters and Metabolic Enzymes

  1. Ming Hu3 and
  2. Xiaoling Li4
  1. Stephen Wang

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch25

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Wang, S. (2011) Interplay between Efflux Transporters and Metabolic Enzymes, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch25

Editor Information

  1. 3

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 4

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA

  1. DMPK/NCDS, Millennium: The Takeda Oncology Company, 35 Landsdowne Street, Cambridge, MA 02139, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • efflux transporters and metabolic enzyme interplay;
  • drug metabolic enzyme, efflux transporter pathways - pathways of drug elimination;
  • bioavailability barrier matrix (BBM), protective filter - of vital organs, highly selective manner

Summary

This chapter contains sections titled:

  • Pathways and functions of drug metabolic enzymes and efflux transporters

  • Interplay between efflux transporters and metabolic enzymes

  • Conclusion

  • References