27. Caco-2 Cell Culture Model for Oral Drug Absorption

  1. Ming Hu1 and
  2. Xiaoling Li2
  1. Kaustubh Kulkarni and
  2. Ming Hu

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch27

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Kulkarni, K. and Hu, M. (2011) Caco-2 Cell Culture Model for Oral Drug Absorption, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch27

Editor Information

  1. 1

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 2

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • Caco-2 cell culture model, oral drug absorption - intestinal absorption, drug metabolism in vitro;
  • Caco-2 cell lines model system - insight into metabolism, transport of drugs in vitro;
  • Caco-2 cell culture model, efficiency and correlativity - also having its drawbacks

Summary

This chapter contains sections titled:

  • Introduction

  • Description

  • Utility

  • Recent progress

  • Significance of Caco-2 cell culture model in drug discovery and development

  • Example

  • Conclusion

  • References