28. MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption

  1. Ming Hu3 and
  2. Xiaoling Li4
  1. Deep Kwatra1,
  2. Sai H. S. Boddu2 and
  3. Ashim K. Mitra1

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch28

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Kwatra, D., Boddu, S. H. S. and Mitra, A. K. (2011) MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch28

Editor Information

  1. 3

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 4

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, 5005 Rockhill Road, Kansas City, MO 64108-2718, USA

  2. 2

    Division of Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • Madin–Darby canine kidney (MDCK) cells, oral drug absorption - cell lines for transport study;
  • cell culture-based permeability-screening models - and effective cell-culture models;
  • cell-culture models, drug transport across intestine - in vitro MDCK cells, wild type, good replacement

Summary

This chapter contains sections titled:

  • Introduction

  • Factors affecting drug absorption through intestine

  • Transporters on GIT

  • Cell culture-based permeability-screening models

  • MDCK and other cells as models for intestinal absorption

  • Summary and conclusion

  • References