29. Intestinal Perfusion Methods for Oral Drug Absorptions

  1. Ming Hu3 and
  2. Xiaoling Li4
  1. Wei Zhu1 and
  2. Eun Ju Jeong2

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch29

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Zhu, W. and Ju Jeong, E. (2011) Intestinal Perfusion Methods for Oral Drug Absorptions, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch29

Editor Information

  1. 3

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 4

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Department of Pharmaceutical Sciences and Clinical Supplies, Merck and Co., Inc., 770 Sumneytown Pike, P.O. Box 4, WP 75B-210, West Point, PA 19486, USA

  2. 2

    Korea Institute of Toxicology (KIT), 19 Sinseongno, Yuseong, Daejeon, 305–343, Republic of Korea

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • intestinal perfusion methods for oral drug absorptions - in situ model, nutrient absorption;
  • data interpretation and method comparison - rate-limiting step, overall disposition process;
  • methodologies, experimental data analysis - intestinal perfusion, using rats

Summary

This chapter contains sections titled:

  • Introduction

  • Applications and recent development of the intestinal perfusion method

  • Intestinal Perfusion in mice and other animals

  • Data interpretation and method comparison

  • Summary

  • Methodologies and experimental data analysis

  • References